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New 1,8-naphthyridine-3-carboxylic acid derivatives were designed, synthesized and evaluated for their  in vivo  antihistaminic activity on guinea pig trachea by using chlorpheniramine maleate as the standard drug.

Design, in silico studies, and synthesis of new 1,8-naphthyridine-3-carboxylic acid analogues and evaluation of their H1R antagonism effects