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Sirt6 upregulation inhibited Ang II-induced ROS generation and DNA DSBs in podocytes, and it shows the cytoprotective effects in podocytes  via  the Nrf2/HO-1 pathway. Sirt6 may be a new therapeutic target for the treatment of CKD.

Sirt6-mediated Nrf2/HO-1 activation alleviates angiotensin II-induced DNA DSBs and apoptosis in podocytes