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A novel Pd/Cu-cocatalyzed carbonylative cyclization by C-H activation and N -dealkylative C-N bond activation has been developed for the chemoselective construction of synthetically useful heterocycles. The N , N -dimethylamine group on o -indolyl- N , N -dimethylarylamines was found to act as both the directing group and reactive component in this C-H carbonylative cyclization reaction. Furthermore, a unique C-H oxidation/carbonylative lactonization of diarylmethylamines is firstly demonstrated under modified reaction conditions, which could be easily applicable to the one-step synthesis of multi-substituted phthalides bearing an N , O -ketal skeleton that is difficult to access by previously reported methods. Mechanistic studies implicate that Pd/Cu-cocatalyzed C-H oxidation/carbonylative lactonization is a sequential reaction system via Cu-catalyzed C(sp 3 )-H oxidation and Pd-catalyzed oxidative carbonylation of the C(sp 2 )-H bond. It was found that trace amounts of water are essential to promote the Cu-catalyzed C(sp 3 )-H oxidation of diarylmethylamine for the formation of the hydroxyl group, which could act as an in situ -formed directing group in the intramolecular carbonylative lactonization step.

Tertiary amine-directed and involved carbonylative cyclizations through Pd/Cu-cocatalyzed multiple C–X (X = H or N) bond cleavage