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Herein, we report Anti-IL-6-USPIO for detecting IL-6 in inflammatory macrophages and MR imaging vulnerable plaques of atherosclerosis in rabbit, which would provide a novel non-invasive strategy for evaluating acute cardiovascular risk or exploiting anti-atherosclerotic drugs.

IL-6-targeted ultrasmall superparamagnetic iron oxide nanoparticles for optimized MRI detection of atherosclerotic vulnerable plaques in rabbits