English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Two novel methods for the preparation of the virtually equimolar mixtures of ( S )- and ( R )-diastereomers of 5-methoxycarbonylhydroxymethyluridine (mchm 5 U) have been developed. The first method involved α-hydroxylation of a 5-malonate ester derivative of uridine (5) with SeO 2 , followed by transformation to ( S )- and ( R )-5-carboxymethyluridines (cm 5 U, 8) and, finally, into the corresponding methyl esters. In the second approach, ( S )- and ( R )-mchm 5 -uridines were obtained starting from 5-formyluridine derivative (9) by hydrolysis of the imidate salt (11) prepared in the acid catalyzed reaction of 5-cyanohydrin-containing uridine (10b) with methyl alcohol. In both methods, the ( S )- and ( R ) diastereomers of mchm 5 U were effectively separated by preparative C18 RP HPLC.

Novel entry to the synthesis of (S)- and (R)-5-methoxycarbonylhydroxymethyluridines – a diastereomeric pair of wobble tRNA nucleosides