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Herein, we focused on developing the feasibility of nano-enabled local anaesthetic (LA) delivery to anaesthetise the full thickness of eyelid skin. For this purpose a temperature-responsive hydrogel poly( N -vinylcaprolactam- co -hyaluronic acid) (p(VCL- co -HA)) was prepared through aqueous emulsion polymerization with a Food and Drug Administration (FDA) approved p(VCL) and hyaluronic acid (HA) showing remarkably high LA drug loading capacity.

Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin