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4-Hydroxytamoxifen ( 4-OHT ), the most common hormone used for the treatment of breast cancer, is a selective estrogen receptor modulator (SERM) inhibitor that acts as an antagonist in breast tissue and a partial agonist in the endometrium; therefore, it increases the risk of uterine cancer while lowering the risk of breast cancer recurrence.

Computational investigations of the binding mechanism of novel benzophenone imine inhibitors for the treatment of breast cancer