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A spectrochemical approach was adopted to study the charge-transfer (CT) complexation of sparfloxacin (SFX) with tetracyanoethylene (TCNE). Definitive screening design (DSD) was used to investigate the reaction variables.

rsc advances

Application of a definitive screening design for the synthesis of a charge-transfer complex of sparfloxacin with tetracyanoethylene: spectroscopic, thermodynamic, kinetics, and DFT computational studies