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Locusts are a kind of agricultural pest rich in protein and widely eaten by people, yet, the nutritional and antioxidant activities of locust peptide have never been explored. In the current study, the locust peptides (LPs) were isolated from the Locusta migratoria manilensis (Meyen, 1835) and the anti-aging effects on Caenorhabditis elegans ( C. elegans ) were evaluated. The mean lifespan of C. elegans was significantly extended using LPs with a concentration of 1.0 mg mL -1 . Out of the 23 peptides, LP-1, a pentapeptide with The-Phe-Lys-His-Gly sequence, with a concentration of 2.5 mg mL -1 significantly extended the lifespan of the worms by 23.5%. Additionally, LP-1 was observed to be a strong free radical-scavenger which can improve the survival of the C. elegans under oxidative stress, thermal stress and UV radiation. Furthermore, the LP-1 can up-regulate the expression of the transcription factor DAF-16 and jnk-1 , suggesting that LP-1 may promote the C. elegans lifespan and stress resistance through a JNK-1-DAF-16 pathway. This study will be significant for the development of locusts and improvement of functional insect peptide production.

Structural characterization of peptides fromLocusta migratoria manilensis(Meyen, 1835) and anti-aging effect inCaenorhabditis elegans