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A series of new 1,4-dihydroindeno[1,2-]pyrazole tethered carbohydrazide hybrids () were designed, synthesized and evaluated for their antimicrobial activity. Compounds , , ,  and  demonstrated significant activity against the entire panel of test pathogens. Further, compounds  and  exhibited significant anti- activity. These potential hybrids ( and ) also exhibited promising ergosterol biosynthesis inhibition against , which was further validated through molecular docking studies. Furthermore, compounds  and  caused intracellular ROS accumulation in  MTCC 3017 and were non-toxic to normal human lung cell line MRC5.  studies revealed that they demonstrated drug likeness and an appreciable pharmacokinetic profile. Overall, the findings demonstrate that  and  may be considered as promising leads for further development of new antifungal drugs.

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Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-<i>c</i>]pyrazole tethered carbohydrazide hybrids: exploring their<i>in silico</i>ADMET, ergosterol inhibition and ROS inducing potential

Design, synthesis, and antimicrobial evaluation of 1,4-dihydroindeno[1,2-c]pyrazole tethered carbohydrazide hybrids: exploring theirin silicoADMET, ergosterol inhibition and ROS inducing potential