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A new class of piano-stool iridium complexes with 1,2-diaminoethane ligands are shown to be effective and safe antimicrobials with activity against Staphylococcus aureus , including various isolates of methicillin-resistant strains (MRSA). Comparison to other piano stool complexes with activity against mycobacteria are made along with a discussion of structure-activity relationships. The structures of one the most active complexes with the ligand cis -1,2-diaminocyclohexane and one of the least active complexes with the ligand trans -1,2-diaminocyclohexane are compared and discussed with respect to their drastically different activities. In vitro toxicity studies for all of the complexes are described. In addition, a mouse study with one of the complexes, [(pentamethylcyclopentadienyl)( cis -1,2-diaminocyclohexane)(chloro)iridium]chloride, showed no ill effects on the mice at high doses.

Iridium piano stool complexes with activity againstS. aureusand MRSA: it is past time to truly think outside of the box