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Combining 2D STD-NMR, computation, biochemical assays and click-chemistry, we have identified a chromogranin-A derived compound ( 5 ) that has high affinity and bi-selectivity for αvβ6 and αvβ8 integrins and is stable in microsomal preparations.

A stapled chromogranin A-derived peptide is a potent dual ligand for integrins αvβ6 and αvβ8