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Follow-on drugs represent the majority of new drug introductions and show improved properties to the pioneer drug. In order to fast-follow, RD diazotization, reduction, unmasking of the hydrazine and Fischer indole reaction). This ‘machine’ is then used to prepare a small library of hitherto unreported analogues of the 5-HT agonist Zolmitriptan in good yields, thus demonstrating that the integration and use of machines is a powerful tool to expedite drug discovery.

A machine-assisted approach for the preparation of follow-on pharmaceutical compound libraries