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An eco-friendly acetylcholine iodide-ethylene glycol (ACI/EG) deep eutectic mixture mediated green protocol has been developed for the synthesis of hitherto unexplored multi-functionalized linear tricyclic spiropyrrolo[1,2- b ]isoquinoline analogues. The effects of the synthesized compounds on the osteoblast differentiation of hBMSC-TERT cell lines were investigated and promising results were observed with significant IC 50 values. In addition, molecular modeling simulations were also performed with the 3D structure of BMP-2 to reveal binding interactions and orientations of highly potent spiropyrrolo[1,2- b ]isoquinoline analogues.

rsc advances

ACI/EG eutectic mixture mediated synthesis, characterization and<i>in vitro</i>osteoblast differentiation assessment of spiropyrrolo[1,2-<i>b</i>]isoquinoline analogues

ACI/EG eutectic mixture mediated synthesis, characterization andin vitroosteoblast differentiation assessment of spiropyrrolo[1,2-b]isoquinoline analogues