English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

There is considerable interest in using positron emission tomography (PET) imaging to understand the function of dopamine D 3 receptors. Due to high sequence homology with D 2 receptors, development of D 3 -selective PET radiotracers has been challenging. In an effort to overcome this issue, we report the radiosynthesis of a new selective D 3 ligand with carbon-11 ( [   11   C] 1  ), and its initial preclincial evaluation as a potential PET radiotracer for in vivo imaging of D 3 receptors. [   11   C] 1  was prepared via [ 11 C]CO 2 fixation in 0.1% non-corrected radiochemical yield, good radiochemical purity (&gt;95%) and high specific activity (&gt;2000 Ci mmol -1 ). [   11   C] 1  exhibited specific binding to D 3 receptors using ex vivo autoradiography experiments with rat brain, but only 14-fold selectivity over D 2 receptors which is lower than the 1400-fold value reported previously for cell studies. Rodent PET imaging revealed reasonable uptake of the radiotracer in areas of the brain known to be rich in D 3 receptors.

Synthesis and pre-clinical evaluation of a potential radiotracer for PET imaging of the dopamine D3 receptor

Synthesis and pre-clinical evaluation of a potential radiotracer for PET imaging of the dopamine D₃ receptor