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Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.

Spy vs. spy: selecting the best reporter for 19F NMR competition experiments

Spy vs. spy: selecting the best reporter for ¹⁹F NMR competition experiments