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The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.

Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity againstPseudomonas aeruginosa