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The Ni-catalyzed reaction of aromatic amides with alkynes in the presence of KOBu  t  involves C-H/N-H oxidative annulation to give 1(2 H )-isoquinolinones. A key to the success of the reaction is the use of a catalytic amount of strong base, such as KOBu  t  . The reaction shows a high functional group compatibility. The reaction with unsymmetrical alkynes, such as 1-arylalkynes, gives the corresponding 1(2 H )-isoquinolinones with a high level of regioselectivity. This discovery would lead to the development of Ni-catalyzed chelation-assisted C-H functionalization reactions without the need for a specific chelation system.

Nickel-catalyzed C–H/N–H annulation of aromatic amides with alkynes in the absence of a specific chelation system