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In the present study, an UHPLC-QTOF MS method was employed to characterize the metabolic profiles of DIOA, DIOC, DIOF, DIOG and DIOM in zebrafish biological samples. The metabolic pathways of these compounds and the fragmentation patterns of the metabolites were proposed.

Metabolism of five diterpenoid lactones from Dioscorea bulbifera tubers in zebrafish