English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Resin glycosides are novel P-glycoprotein inhibitors. In order to evaluate their multidrug resistance (MDR) reversal activities, we isolated seven new resin glycosides, pharbitins A–G (1–7) from the seeds of Pharbitis nil. Their chemical structures were determined by extensive application of high resolution 2D NMR techniques, HRESIMS and chemical methods. Compounds 1–4 and 6 were evaluated for their MDR reversal activities in KB/VCR, A549/T and K562/ADR cells. Among them, compound 2 showed moderate MDR reversal activity in KB/VCR cells, and increased the cytotoxicity of vincristine by 2.2-fold when incorporated at 25 μM. A structure–activity relationship study revealed that substituting Rha′′ C-3 with a trans-cinnamoyl group improves the MDR reversal activity. Also, an intracellular Rh123 accumulation assay demonstrated that compound 2 could inhibit the function of P-gp.

Pentasaccharide resin glycosides with multidrug resistance reversal activities from the seeds of Pharbitis nil