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Collagen–silver/gold biomimetic matrices were developed for cardiac tissue engineering. The incorporation of nanoparticles led to modifications in the 3D structure of the collagen matrices, with gold increasing the materials' viscosity by ≈4 times. Electrical conductivity was also enhanced upon addition of the nanoparticles. The materials promoted reparative macrophage migration and improved the proliferation and function of neonatal cardiomyocytes under electrical stimulation.

Multi-functional thermo-crosslinkable collagen-metal nanoparticle composites for tissue regeneration: nanosilver vs. nanogold