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For combinatorial monitoring and chemotherapy of liver carcinoma, the macromolecular prodrug based on hyaluronic acid and doxorubicin hydrochloride was prepared by an acid-labile linkage and conjugated with amine-modified iron oxide nanoparticles.

rsc advances

Surface functionalization of superparamagnetic nanoparticles by an acid-liable polysaccharide-based prodrug for combinatorial monitoring and chemotherapy of hepatocellular carcinoma