English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Multifunctional nanoplatforms based on mesoporous silica nanoparticles (MSNs) have recently shown great promise in drug delivery and therapy. Herein, a multifunctional nanoplatform based on MSNs is fabricated by a modified micro-emulsion method for drug delivery and imaging-guided chemo/photodynamic synergistic therapy. Carbon dots (C-dots) and a photosensitizer, rose bengal (RB), are embedded in the core/shell structured MSNs to form MSN@C-dots/RB nanoparticles, in which C-dots can serve as a fluorescence probe to achieve cell fluorescence imaging and RB can generate singlet oxygen to perform photodynamic therapy. MSN@C-dots/RB nanoparticles can efficiently prevent the self-aggregation-induced quenching of photosensitizer molecules, which facilitates a large production of cytotoxic singlet oxygen and thus an enhanced PDT efficacy. Furthermore, a remarkable chemo/photodynamic synergistic anti-tumor effect was achieved with MSN@C-dots/RB nanoparticles loaded with doxorubicin (DOX) under green light irradiation. In addition, a significant bacterial inhibitory effect has been achieved by the antimicrobial assay via loading ampicillin in the MSNs@C-dots/RB nanoparticles, thereby demonstrating the versatility of this multifunctional nanoplatform. The results revealed that this MSN-based chemo/photodynamic synergistic nanoplatform has great promise in imaging assisted cancer therapy and bacteria inhibition.

A multifunctional nanoplatform based on mesoporous silica nanoparticles for imaging-guided chemo/photodynamic synergetic therapy