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Antimicrobial and antibiofilm activities were evaluated. Two compounds ( 5b  and  5e ) were identified as the hits against  S. epidermidis . Compounds  5b  and  5e  showed promising antibacterial and antibiofilm activities.

2,3-Disubstituted-1,4-naphthoquinones containing an arylamine with trifluoromethyl group: synthesis, biological evaluation, and computational study