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An efficient modular approach for the synthesis of propargylamine modified beta-cyclodextrins has been developed. Using mono-(6-benzylamino-6-deoxy)-beta-cyclodextrins, formaldehyde, and alkynes, mono-(6-(benzylpropargyl)amino-6-deoxy)-beta-cyclodextrins have been synthesized through a three-component coupling reaction catalyzed by gold(III) salt in water at 40 degrees C.Department of Applied Biology and Chemical Technology2016-2017 > Academic research: refereed > Publication in refereed journalbcr

Modular synthesis of propargylamine modified cyclodextrins by a gold(iii)-catalyzed three-component coupling reaction