English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

o-Aminophenol-N,N,O-triacetate, known as APTRA, is one of the most well-established ligands for targeting magnesium ions but, like other aminocarboxylate ligands, it binds Ca 2+ much more strongly than Mg 2+ . The synthesis of an O-phosphinate analogue of APTRA is reported here, namely o-aminophenol-N,N-diacetate-O-methylene-methylphosphinate, referred to as APDAP. Metal binding studies monitored using UV-visible spectroscopy show that the affinity of APDAP for Ca 2+ is reduced by over two orders of magnitude compared to APTRA, and for Zn 2+ by over three orders of magnitude, whereas the affinity for Mg 2+ is attenuated to a much lesser extent, by a factor of only about 7. The selectivity towards Mg 2+ is thus substantially improved. DFT calculations support the notion that longer P-O and P-C bonds in APDAP (compared to corresponding C-O and C-C bonds in APTRA) favour a larger angle at the metal, an effect that is less unfavourable for smaller ions like Mg 2+ han for larger ions such as Ca 2+ . Derivatives of APDAP can be anticipated that will offer improved sensing of Mg 2+ in the presence of Ca 2+ , in the physiologically important millimolar concentration range.

Enhanced selectivity for Mg2+with a phosphinate-based chelate: APDAPversusAPTRA

Enhanced selectivity for Mg²⁺with a phosphinate-based chelate: APDAPversusAPTRA