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The inverse electron-demand Diels-Alder reaction between tetrazine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radiosynthesis of 225 Ac-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothiocyanate couplings.

The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of225Ac-labelled radioimmunoconjugates

The inverse electron-demand Diels–Alder reaction as a new methodology for the synthesis of²²⁵Ac-labelled radioimmunoconjugates