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An efficient synthesis of Betti bases via a one-pot three-component reaction of 2-naphthol, substituted aldehydes and anilines in aqueous media is reported. Through screening different catalysts, reverse zinc oxide nanomicelles show good activity and high selectivity. The catalyst retained activity after six cycles of reuse and were recoverable. The method has the advantages of atom economy, short reaction time, good yield, and easy work-up as well as being environmental friendly.

Highly efficient one-pot three-component Betti reaction in water using reverse zinc oxide micelles as a recoverable and reusable catalyst