English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Three rare sesquiterpene lactone dimers, dicarabrol A (1), dicarabrone C (2) and dipulchellin A (3), were isolated from the whole plants of Carpesium abrotanoides. Their structures were elucidated by comprehensive analyses of NMR and MS spectroscopic data. The structure of dipulchellin A was further confirmed by single-crystal X-ray crystallography. Compounds 1 and 2 possessed an unusual carbon skeleton with two carabranolide moieties linking through a spirotetrahydrofuran ring, which was presumably formed by a [4 + 2] cycloaddition. Compound 3 was a [3 + 2] cycloaddition product of a guaianolide moiety and a carabranolide moiety linking through a cyclopentane ring. Their plausible biosynthetic pathways were also proposed. Compounds 1–3 showed moderate cytotoxicity against HL-60 cells with IC50 values of 8.7 ± 0.3, 8.2 ± 0.3 and 8.9 ± 0.4 μM, respectively.

Dicarabrol A, dicarabrone C and dipulchellin A, unique sesquiterpene lactone dimers from Carpesium abrotanoides