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We report a new simple synthesis method for a DNA-anchored SERS nanoprobe encoded with a Raman reporter by a one-pot overgrowth process, allowing the nanostructure to be controllably tuned to provide improved Raman enhancement, and simultaneously introduce Raman reporters and DNA onto nanoparticles whilst retaining their SERS activity and bio-recognition ability.

One-pot synthesis of a DNA-anchored SERS nanoprobe with simultaneous nanostructural tuning and Raman reporter encoding