English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The present study strongly relates to ongoing research on the development of cationic polymers which are\udof great interest due to their enormous potential for biomedical applications, especially as non-viral vectors\udfor gene therapy, antimicrobial agents and active components in DNA sensing devices. The current paper\uddemonstrates that a functional group approach can be successfully realized in a free-radical\udcopolymerization process to prepare cationic copolymers with a desired composition of amine groups,\udwhich can be protonated in water thus, providing electrostatic interactions between a polycation and\udDNA. Three replicas of the cationic copolymer, acrylamide/3-(N,N-dimethylaminopropyl)-acrylamide\ud(AADMAPA), were synthesized using this strategy. The values of average molecular mass and\udpolydispersity index, are similar for the replicas, averaged to 24 000   2000 g mol1 and 1.5   0.1,\udrespectively. The copolymer composition according to 1\udH-NMR (D2O), was corresponded to the molar\udratio of initial monomers. The dynamic light scattering studies and zeta potential measurements\udconfirmed that in water positively charged AADMAPA/DNA polyplexes are formed at N/P > 2.2: the\udformed particles have bimodal distributions with the average diameters of 70 and 700 nm. Zeta potential\udmeasurements indicated that the point of zero charge (isoelectric point) is close to N/P y 2.2.\udAccording to the atomic force microscopy positively charged AADMAPA/DNA polyplexes have axially\udsymmetric shapes.The authors are grateful to Prof. Babushkina T. A., Mrs Klimova\udT. P. for helpful discussion and NMR spectral data. The authors\udalso acknowledge Mrs Klemenkova Z. S. for IR spectral data. E.\udLaukhina acknowledges the support from Instituto de Salud\udCarlos III, through “Acciones CIBER”. The Networking Research\udCenter on Bioengineering, Biomaterials and Nanomedicine\ud(CIBER-BBN), an initiative funded by the VI National R&D&I\udPlan 2008-2011, Iniciativa Ingenio 2010.Peer reviewe

Towards DNA sensing polymers: interaction between acrylamide/3-(N,N-dimethylaminopropyl)-acrylamide and DNA phage λ at various N/P ratios