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N ε -Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N ε -trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N ε -trimethyllysine.

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-Nε-trimethyllysine

Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N^ε-trimethyllysine