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We have designed and synthesized a novel series of fourteen alkylated purines with notable in vitro anti-proliferative activities against three cancerous cell lines. In vivo studies show absorption by the oral route of administration with systemic distribution and low toxicity for the two more active derivatives.

p-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents