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The effect of aTNA (acyclic threoninol nucleic acids) units on the stability of intramolecular i-motifs was investigated by spectroscopic techniques. The replacement of selected positions of the C-core can modulate the stability at different pH ranges.This work was supported by Spanish Ministry of Economy and Competitiveness\ud(grants CTQ2014-52588-R and CTQ2012-38616-C02-02), the Generalitat de\udCatalunya (grant 2014 SGR 1106; 2014 SGR 187) and the Communities\udMULTIFUN (contract NMP4-LA-2011-262943). CIBER-BBN is an initiative funded\udby the VI National R&D&I Plan 2008–2011, Iniciativa Ingenio 2010, Consolider\udProgram, CIBER Actions and financed by the Instituto de Salud Carlos III with\udassistance from the European Regional Development Fund.Peer reviewe

Modulation of the stability of i-motif structures using an acyclic threoninol cytidine derivative