English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

A green scalable flow-synthesis process for the production of eugenyl acetate, an eugenol derivative with\udpotential applications in food and medicinal chemistry, was developed. Through batch experiments, the\udanion-exchange resin Amberlyst A-21 was recognized as a suitable catalyst for the esterification of\udeugenol with acetic anhydride. Next, the process was switched from batch- to flow-mode by using a\udpacked-bed microreactor integrated in an instrumental platform that permitted at the same time\udcontinuous control of the main process parameters (flow rate, feed mixture composition, temperature)\udand the on-line HPLC analysis of the reactor effluent. Thanks to this apparatus, a number of experiments\udwith different reaction conditions have been easily performed to evaluate the effects of temperature and\udreagent molar ratios on eugenyl acetate production. The results have been used to carry out a central\udcomposite rotatable experimental design (CCRD) whose derived response surface model (RSM)\udsuggested an optimal temperature and acetic anhydride to eugenol molar ratio of 95 °C and 3 : 1,\udrespectively. The goodness of these theoretically deduced parameters has been experimentally\udconfirmed obtaining, with a flow rate of 40 mL min-1, a 95% conversion. The Amberlyst A-21 packed-bed\udmicroreactor also demonstrated good long-term stability ensuring, under the above optimized\udconditions, a high and stable conversion (over 93%) for prolonged reaction times

Continuous ion-exchange resin catalysed esterification of eugenol for the optimized production of eugenyl acetate using a packed bed microreactor