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International audienceThe potential of self-assembled nanoparticles (NPs) containing the fine tunable pH-responsive properties of the hydrophobic poly[2-(diisopropylamino)ethyl methacrylate] (PDPA) core and the protein repellence of the hydrophilic poly[N(2-hydroxypropyl)methacrylamide] (PHPMA) shell for in vitro cytostatic activity has been explored on cancer cells. The amphiphilic diblock copolymer poly[N-(2-hydroxypropyl)methacrylamide]-b-poly[2-(diisopropylamino)ethyl methacrylate] (PHPMA-b-PDPA) synthesized by a reversible addition–fragmentation chain transfer (RAFT) technique allows for excellent control of the polymer chain length for methacrylamides. The PHPMA-b-PDPA block copolymer dissolved in an organic solvent(ethanol/dimethylformamide) undergoes nanoprecipitation in phosphate buffer saline (PBS, pH ∼ 7.4) and self-assembles into regular spherical NPs after solvent elimination. The NPs’ structure was characterized in detail by dynamic (DLS), static (SLS) and electrophoretic (ELS) light scattering, small angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM). The PHPMA chains prevented the fouling of proteins resulting in a remarkable stability of the NPs in serum....

polymer chemistry

Nanoparticles of the poly([N-(2-hydroxypropyl)]methacrylamide)-b-poly[2-(diisopropylamino)ethyl methacrylate] diblock copolymer for pH-triggered release of paclitaxel