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The new prosthetic group 18F-TEG-DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c.) of 34 ± 5%. Copper-free click cycloadditions with an azido-cRGD, a folate-azide and two α-MSH analogue azido-peptides resulted in very high RCYs and fast reaction kinetics.

A 18F-labeled dibenzocyclooctyne (DBCO) derivative for copper-free click labeling of biomolecules

A ¹⁸F-labeled dibenzocyclooctyne (DBCO) derivative for copper-free click labeling of biomolecules