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A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Dynamic nuclear polarization of biocompatible13C-enriched carbonates for in vivo pH imaging

Dynamic nuclear polarization of biocompatible¹³C-enriched carbonates for in vivo pH imaging