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Bioactive glasses doped with silver are aimed to minimize the risk of microbial contamination, and therefore, the influence of silver on the bioactive properties is an intense investigated task. However, the information related to the role played by silver, when added to the bioactive glass composition, on the biocompatibility properties is scarce. This aspect is essential as long as the silver content can influence the blood protein adsorption onto glass surface, affecting thus the material biocompatibility. Therefore, from the perspective of the biocompatibility standpoint, the finding of an optimal silver content in a bioactive glass is an extremely important issue. In this study, silver doped bioactive glasses were prepared by melt-derived technique, which eliminates the pores influence in the protein adsorption process. The obtained glasses were characterized by X-ray diffraction, UV-vis, X-ray Photoelectron (XPS) and Fourier Transform Infrared (FT-IR) spectroscopy, and afterwards they were investigated in terms of protein adsorption. Both UV-vis and XPS spectroscopy revealed the presence of Ag+ ions in all silver containing samples. By increasing the silver content, metallic Ag0 appears, the highest amount being observed for the sample with 1 mol% AgO2. Electron Paramagnetic Resonance measurements evidenced that the amount of spin labeled serum albumin attached on the surface increases with the silver content. The results obtained by analyzing the information derived from Atomic Force Microscopy and FT-IR measurements indicate that the occurrence of metallic Ag0 in the samples structure influences the secondary structure of the adsorbed protein. Based on the results derived from the protein response upon interaction with the investigated glass calcium-phosphate based system it was determined the optimal silver oxide concentration for which the secondary structure of the adsorbed protein is similar with that of the free one. This concentration was found to be 0.5 mol%

Addressing the optimal silver content in bioactive glass systems in terms of BSA adsorption