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Hydrogen sulphide (H 2 S) is an endogenous mediator of human health and disease, but precise measurement in living cells and animals remains a considerable challenge. We report the total chemical synthesis and characterization of three 1,2-dioxetane chemiluminescent reaction-based H 2 S probes, CHS-1, CHS-2 , and CHS-3. Upon treatment with H 2 S at physiological pH, these probes display instantaneous light emission that is sustained for over an hour with high selectivity against other reactive sulphur, oxygen, and nitrogen species. Analysis of the phenol/phenolate equilibrium and atomic charges has provided a generally applicable predictive model to design improved chemiluminescent probes. The utility of these chemiluminescent reagents was demonstrated by applying CHS-3 to detect cellularly generated H 2 S using a multi-well plate reader and to image H 2 S in living mice using CCD camera technology.

Chemiluminescent probes for imaging H2S in living animals

Chemiluminescent probes for imaging H₂S in living animals