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NMR investigations of the kinetics and thermodynamics of the competitive binding of L-methionine (Met), L-histidine (His), and 5′-monophosphates of guanosine (5′-GMP), adenosine (5′-AMP), thymidine (5′-TMP) and cytidine (5′-CMP) to [Pt(dien)Cl]+ (dien = 1,5-diamino-3-azapentane) in aqueous solution show that 5′-GMP selectively displaces S-bound Met, a finding which has implications for DNA platination by anticancer drugs in vivo

journal of the chemical society chemical communications

Intermolecular displacement of S-bound<scp>L</scp>-methionine on platinum(<scp>II</scp>) by guanosine 5′-monophosphate: implications for the mechanism of action of anticancer drugs

Intermolecular displacement of S-boundL-methionine on platinum(II) by guanosine 5′-monophosphate: implications for the mechanism of action of anticancer drugs