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Three new bicyclic depsipeptides, which are related to the previously reported thailandepsins A ( 1 ), B ( 2 ) and C ( 3 ), were discovered from the culture broth of Burkholderia thailandensis E264 when supplemented with amino acid precursors, and were subsequently named as thailandepsins D ( 4 ), E ( 5 ) and F ( 6 ), respectively. Enzyme assays showed that 1-6 are potent histone deacetylase (HDAC) inhibitors, particularly toward HDAC1 which represents class I human HDACs.

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264