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Multifunctional iron oxide (FeOx) magnetic nanoparticles (MNPs) are promising items for biomedicalapplications. They are studied as theranostic agents for cancer treatment, selective probes forbioanalytical assays, controllable carriers for drug delivery and biocompatible tools for cell sorting ortissue repair. Here we report a new method for the synthesis in water of FeOx–MNPs via a top-downphysical technique consisting in Laser Ablation Synthesis in Solution (LASiS). LASiS is a greenmethod that does not require chemicals or stabilizers, because nanoparticles are directly obtained inwater as a stable colloidal system. A gamut of characterization techniques was used for investigatingthe structure of FeOx–MNPs that have a polycrystalline structure prevalently composed of magnetite(ca. 75%) and hematite (ca. 22%). The FeOx–MNPs exhibit very good magnetic properties if comparedto what is usually reported for iron oxide nanoparticles, with saturation magnetization close to the bulkvalue (ca. 80 emu g1) and typical signatures of the coexistence of ferrimagnetic and antiferromagneticphases in the same particle. The functionalization of FeOx–MNPs after the synthesis was possible witha variety of ligands. In particular, we succeeded in the functionalization of FeOx–MNPs withcarboxylated phosphonates, fluorescent alkylamines, fluorescent isothiocyanates and bovine serumalbumin. Our FeOx–MNPs showed excellent biocompatibility. Multifunctional FeOx–MNPs wereexploited for macrophage cell labelling with fluorescent probes as well as for cell sorting andmanipulation by external magnetic fields

Top-down synthesis of multifunctional iron oxide nanoparticles for macrophage labelling and manipulation