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A series of quantum dot (QD) ligands are reported that can make strong polyelectrolyte QD surfaces with sulfonates or quaternary ammoniums, which can endow QDs with excellent colloidal stability independent of the pH and ionic strength, minimal hydrodynamic size, and can be exploited to achieve stable and flexible bioconjugations and layer-by-layer assembly.

Strong polyelectrolyte quantum dot surface for stable bioconjugation and layer-by-layer assembly applications