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The first passage probability (FPP), of trafficked intracellular particlesreaching a displacement L, in a given time t or inverse velocity S = t/L, canbe calculated robustly from measured particle tracks, and gives a measure ofparticle movement in which different types of motion, e.g. diffusion, ballisticmotion, and transient run-rest motion, can readily be distinguished in a singlegraph, and compared with mathematical models. The FPP is attractive in that itoffers a means of reducing the data in the measured tracks, without makingassumptions about the mechanism of motion: for example, it does not employsmoothing, segementation or arbitrary thresholds to discriminate betweendifferent types of motion in a particle track. Taking experimental data fromtracked endocytic vesicles, and calculating the FPP, we see how three moleculartreatments affect the trafficking. We show the FPP can quantify complicatedmovement which is neither completely random nor completely deterministic,making it highly applicable to trafficked particles in cell biology.

The First Passage Probability of Intracellular Particle Trafficking