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Determination of the microdistribution of trace elements in bone at low concentrations has previously been performed with proton induced X-ray emission (PIXE), high-energy synchrotron source X-ray fluorescence (XRF) and laser ablation - inductively coupled plasma mass spectrometry (LA-ICP-MS). Several commercial benchtop XRF systems with micrometer-scale resolution are currently available. While providing convenient, non-destructive mapping capability, they appear to lack the sensitivity required for detection of trace elements in biological tissues such as bone. We investigated the application of a prototype benchtop XRF system for the measurement of strontium and lead at physiological levels in bone. Detection of several elements of interest, including Sr and Pb was achieved with an experimental set up based on focused monochromatic microbeam X-ray fluorescence (Mµ-XRF) instrumentation with a low power source (45 W molybdenum tube) coupled to doubly curved crystal (DCC) optics. A cross-section of bone about 5 mm × 8 mm size was mapped with 80-µm resolution showing heterogeneous distribution of Sr and Pb. The data showed that Mµ-XRF coupled to DCC is powerful method for measurement of the spatial distribution of trace elements in bone.

Measurement of the microdistribution of strontium and lead in bone via benchtop monochromatic microbeam X-ray fluorescence with a low power source