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The biotin-based low molecular weight hydrogel (G1) is able to entrap the epMB and as a consequence, the color of the epMB changes from green to blue; the color change depends on the state of the gelator, i.e. upon proceeding from sol to gel and vice versa.

Reversible sol–gel signaling system with epMB for the study of enzyme- and pH-triggered oligonucleotide release from a biotin hydrogel