English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

With the success of cisplatin (cis-diamminedichloroplatinum(II)), strong interest has developed in the application of inorganic metal complexes to the treatment of cancer. Research has focused on platinum(II) complexes with a variety of spectator ligands that provide novel physicochemical properties. In this paper we report a kinetic study of 1',1'-bis(diphenylphosphino)ferrocenedichloroplatinum(II) and two related compounds with either an acetate or amide ester substituent attached to the cyclopentadienyl ring. For all compounds the reactivity towards L-cysteine and L-methionine in aqueous solution has been investigated (25 degrees C, I= 0.010 M and pseudo-first-order conditions). For the reactions with l-cysteine and l-methionine the reactions proceeded via a steady-state aquated intermediate to form mono (0.92(2)-3.25(4)) x 10(-3) s(-1)) and bis adducts (0.97(2)-3.67(4)) x 10(-4) s(-1)). For reactions with l-cysteine, direct reactions with the starting complex also contributed (mono adduct: 0.36(2)-1.41(4) M(-1) s(-1), bis adduct: 0.080(1)-0.96(1) M(-1) s(-1)). The attached substituents were found to have a significant effect upon the reaction kinetics, with the substituted complexes found to have increased reactivity. It is proposed that the increased reactivity stems from hydrogen bonding between the substituent and the entering ligand and subsequent outer-sphere complex stabilisation. Evidence in support of this theory was obtained form measurements in dichloromethane with 1-propanethiol as the entering ligand. The reactivity of the dppf containing complexes was also compared to that of cisplatin (mono adduct: (0.170(1)-0.175(1)) x 10(-3) s(-1), bis adduct: (0.183(1)-0.397(1)) x 10(-4) s(-1)) and found to be significantly enhanced.

A comparative kinetic study of modified Pt(dppf)Cl2 complexes and their interactions with l-cys and l-met