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The gut-associated circulating anodic antigen (CAA) is one of the major excretory antigens produced by the parasite Schistosoma mansoni. The immunoreactive part of CAA is a threonine-linked polysaccharide composed of long stretches of the unique repeating disaccharide--&gt;6)-[beta-D-GlcpA-(1--&gt;3)]-beta-D-GalpNAc-(1--&gt;. Previously, using surface plasmon resonance and ELISA techniques, it has been shown that some anti-CAA IgM monoclonal antibodies (MAbs) also recognize members of a series of bovine serum albumin (BSA)-coupled synthetic di- to penta-saccharide fragments of the CAA glycan. To generate information on the molecular level about the glycan specificity of the relevant IgM MAbs, two series of oligosaccharides related to the CAA disaccharide epitope were synthesized, and coupled to BSA. The first three analogues, beta-D-GlcpA-(1--&gt;3)-[small beta]-D-GlcpNAc-(1--&gt;O), beta-D-GlcpNAc-(1--&gt;6)-[beta-D-GlcpA-(1--&gt;3)]-beta-D-GlcpNAc-(1--&gt;O), and beta-D-GlcpA-(1--&gt;3)-beta-D-GlcpNAc-(1--&gt;6)-[beta-D-GlcpA-(1--&gt;3)]-beta-D-GlcpNAc-(1--&gt;O), wherein the native beta-D-GalpNAc moiety was replaced by beta-D-GlcpNAc, were synthesized to investigate the specificity of the selected MAbs to the carbohydrate backbone of CAA. The second series of analogues, beta-D-Glcp6S-(1--&gt;3)-beta-D-GalpNAc-(1--&gt;O), beta-D-GalpNAc-(1--&gt;6)-[beta-D-Glcp6S-(1--&gt;3)]-beta-D-GalpNAc-(1--&gt;O), and beta-D-Glcp6S-(1--&gt;3)-beta-D-GalpNAc-(1--&gt;6)-[beta-D-Glcp6S-(1--&gt;3)]-beta-D-GalpNAc-(1--&gt;O), wherein the native beta-D-GlcpA moiety was replaced by beta-D-Glcp6S, was synthesized to evaluate the importance of the type/nature of the charge of CAA for the MAb recognition.

organic and biomolecular chemistry

Synthesis and conjugation of oligosaccharide analogues of fragments of the immunoreactive glycan part of the circulating anodic antigen of the parasite Schistosoma mansoni