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Intracellular lipid binding proteins (iLBPs) play a role in the transport and cellular uptake of fatty acids and gene expression regulation. The aim of this work was to characterize the  iLBP  gene family of the Pacific oyster  Crassostrea gigas , one of the most cultivated marine bivalves in the world, using bioinformatics and molecular biology approaches. A total of 26 different  iLBPs  transcripts were identified in the Pacific oyster genome, including alternative splicing and gene duplication events. The oyster  iLBP  gene family seems to be more expanded than in other invertebrates. Furthermore, 3D structural modeling and molecular docking analysis mapped the main amino acids involved in ligand interactions, and comparisons to available protein structures from vertebrate families revealed new binding cavities. Ten different  CgiLBPs  were analyzed by quantitative PCR in various tissues of  C. gigas,  which suggested differential prevalent gene expression of  CgiLBPs  among tissue groups. The data indicate a wider repertoire of  iLBPs  in labial palps, a food-sorting tissue. The different gene transcription profiles and reported docking systems suggest that the iLBPs are a non-generalist ligand binding protein family with specific functions.

Intracellular lipid binding protein family diversity from Oyster Crassostrea gigas: genomic and structural features of invertebrate lipid transporters